This is an important contribution, adding to the understanding of bone remodeling, which is not just relevant to arthritis but also to degenerative bone changes. Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis results in the formation of new . Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK (a) Microphotographs of toluidine blue–stained joint sections of, ”from.

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Skip to search form Skip to main content. Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid arthritis leads to bone resorption. The molecular basis of these different patterns of joint disease is unknown.

Dickkopf-1 is a master regulator of joint remodeling.

tegulator This paper has highly influenced 44 other papers. From This Paper Figures, tables, and topics from this paper. Rheumatoid Arthritis Search for additional papers on this topic.


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Dickkopf-1 is a master regulator of joint remodeling

Osteophyte tumor necrosis Neurodegenerative Disorders Bone Resorption. Bone Tissue pediatric intracranial germ cell brain tumor. Citations Publications citing this paper. Showing of extracted citations. Bone Loss in Rheumatoid Rehulator Gravallese Calcified Tissue International Wnt signaling in bone formation and its therapeutic potential for bone diseases.

He Therapeutic advances in musculoskeletal disease Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway.

Melissa M MatzelleMaxime A. Gravallese Arthritis and rheumatism Synovial DKK1 expression is regulated jonit local glucocorticoid metabolism in inflammatory arthritis R. A rate-limiting id for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody.

References Publications referenced by this paper. Showing of 34 references. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

Maini Journal of autoimmunity Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Efficient delivery of small interfering RNA to regulattor tumors by using atelocollagen in vivo. WalshTania N. Gravallese Immunological reviews HolmenTroy A. Williams Journal of bone and mineral research: Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis.


Figure 3 New bone formation next to inflamed joints is increased upon blockade of DKK Black arrows indicate areas of proteoglycan deposition.

Scale bar, 40 mm. Microphotographs show von Kossa staining first and second from leftMovat staining second from right, black arrows and in situ hybridization for osteocalcin right, black arrow. Scale bars, 40 mm left image and mm. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

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