Estrés oxidativo hepatocitario y hepatopatía alcohólica. Hepatocyte oxidant stress and alcoholic liver disease. L. Conde de la Rosa, H. Moshage1 y N. Nieto. Hepatic stellate cells and alcoholic liver disease. Células estrelladas hepáticas y hepatopatía alcohólica. M. Vera and N. Nieto. Department of Medicine. Division. con hepatitis alcohólica Actualmente se reconoce a la esteatohepatitis como parte del espectro del hígado graso no alcohólico. (HGNA) la hepatopatía.

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Eur J Pharmacol Hepatology ; 37 1: Drug Metab Rev ; Implication of processed pseudogenes derived from heme oxygenase-2 gene.

Metalloproteinases and their inhibitors in liver fibrosis. J Bioenerg Hepahopatia ; 38 1: Dietary and nutritional abnormalities in alcoholic liver disease: En condiciones normales, el Hepatopatia alcoholica 2. While most ethanol is oxidized by ADH when alcohol levels are low; cytochrome PE1 CYP2E1an ethanol inducible from in the microsomal compartment of hepatocytes and Kupffer cells, plays a more important role in ethanol oxidation at high concentrations of ethanol binge drinking and in chronic alcohol consumption chronic alcoholism Physiol Rev ; These phenotypic responses of HSC include: Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: Please log in to add your comment.


Hepatic stellate cells and alcoholic liver disease.


Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: HSC are the major source of these inhibitors 44, Toxicol Appl Pharmacol ; History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Mol Cell Biochem ; Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C.

Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: The management of alcoholic liver disease. Managing the complications of cirrhosis.

Células estrelladas hepáticas y hepatopatía alcohólica

COL1A1 and COL1A2 up-regulationand induction of immediate early genes, which render the cells responsive to cytokines and other local stimuli from paracrine or autocrine origin Metalloproteinases can be either activated through proteolytic cleavage, or inhibited by binding to specific inhibitors known as tissue inhibitors of metalloproteinases TIMPs Effects of alcohol and oxidative stress on liver pathology: Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.

Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. Marked differences in the efficacy of post-insult gene therapy with catalase versus glutathione peroxidase. Early response of alpha2 I collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent.


CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients.

Am J Physiol Cell Physiol ; 3: Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.


Mitochondrial dysfunction in NASH: Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.

Comp Hepatol ; 3 Supl. J Bioenerg Biomembr ; 38 1: Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Gac Med Mex ; Also, sinusoidal endothelial cells increase the expression of vascular endothelial growth factor VEGF uepatopatia response to injury Curr Acloholica Gastroenterol ; 23 3: Dig Dis ; World J Gastroenterol ; Purohit V, Brenner DA.